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Pepper Bio wants to reduce those costs by getting drug developers to the right targets faster, using what it calls a "transomics" approach. Pepper Bio also looks at protein phosphorylation, an indication of how and when proteins are active. Pepper Bio CEO Jon Hu said working with Merck gave the startup insight into the needs of the pharma firms to which Pepper Bio hopes to sell its software. "It allows us to understand, truthfully, what drug developers are struggling with," he said. Here's the 20-slide pitch deck that got Pepper Bio $6.5 million in seed funding.
Persons: Pepper, Pepper Bio's cofounders, Jon Hu Organizations: Business, NFX, Silverton Partners, Mana Ventures, Tensility Ventures, VSC Ventures, Merck, Merck Digital Sciences, pharma
It’s hard to say precisely when Silverton, Colo., started to come apart, but the town election of April 7, 2020, might be a good moment to begin the story. That was when a young, progressive New York lawyer and adventure skier named Shane Fuhrman beat the longtime fire chief Gilbert Archuleta, part of Silverton’s old guard, by 10 votes to become the new mayor. To supporters, mainly of his generation, Fuhrman, 42, represented progress. After working at top finance firms in Manhattan, he had returned to his native Colorado and renovated the old Wyman Hotel on Greene Street, not in the mountain-town Victorian style of the Grand Imperial a block away, but as an elegant, hip boutique inn, with rooms going for as much as $385 a night. To Fuhrman’s opponents in the former mining town of 796 residents, he was the incarnation of the T Word, Telluride, and the A Word, Aspen, with their staggering housing prices, luxury outposts and billionaire denizens.
Persons: Shane Fuhrman, Gilbert Archuleta, Wyman Organizations: Aspen Locations: Silverton, Colo, New York, Manhattan, Colorado, Greene, Imperial, Telluride
Renewable energy is more reliable but its promise for the region still remains largely unmet. Most households have depended on gasoline generators for power, but recently the government removed a gasoline subsidy, prompting increased interest in solar power, according to dealers. The Nigerian government has not announced incentives to promote solar energy, such as reducing import taxes on solar equipment as demanded by dealers. “The problem was affordability, but now customers can pay installments over a period of 18 months,” said Tunde Oladipupo, an agent for Sun King, a solar power company. Another example of this shift is the Ford vehicle assembly plant in Silverton, Pretoria, which currently sources over 35% of its electricity from solar power.
Persons: Rashmi Shah, , William Ruto, Tunde Oladipupo, Sun King, Monsurat Qadri, ” Qadri, ” Mohammed Ettu, Shah, ” Shah, ___ Adebayo, Magome Organizations: Climate Summit, World Bank, CP Solar’s, Associated Press, Kenyan, Solutions, Ford, South, CP, Kenya Power, Lighting Company, Supersport, AP Locations: NAIROBI, Mombasa, Nairobi, Kisii County, Kenya, Africa, Nigeria, Oyo, Lagos, Saharan Africa, South Africa, Stillwater, American, Silverton , Pretoria, Mpumalanga, Kenya —, Abuja, Johannesburg
What Courtney Dauwalter Learned in the Pain Cave
  + stars: | 2023-08-31 | by ( Rebecca Byerly | ) www.nytimes.com   time to read: +2 min
After running for 60 miles through snow, up steep, root-filled switchbacks with thousands of feet of elevation gain, Courtney Dauwalter entered what she calls her pain cave. Scott Jurek won Western States seven times (most recently in 2005) but never once ran as fast as Dauwalter did this year. She beat a 1994 Western States record set by Ann Trason, who won the race 14 times, by more than two hours. Now she is trying to do something even the most accomplished ultrarunners would consider extraordinary: win three highly competitive 100-mile races in a single summer. She has won the race twice and currently holds the women’s record.
Persons: Courtney Dauwalter, , Scott Jurek, Ann Trason, Mickey Mouse, billy Organizations: Western Locations: Sierra Nevada, ultrarunning, Moab , Utah, Western, Silverton, Colo, Blanc, Chamonix, France
With Kinjo, kids can earn virtual currency called Robux by playing higher-ranked learning games. To earn these Robux, kids can spend real-world money, or they can play simple mini games to "grind" for Robux rewards. Kids who use Kinjo are three times more likely to spend time on games that are more productive than kids without Kinjo, Malcolm said. Many edtech gaming platforms are already on the market, such as the social-emotional learning game Social Cipher or the STEM learning game Royelles. Check out the 16-slide pitch deck that Kinjo used to raise $6.5 million in seed funding:
Persons: Charles Thornburgh couldn't, Thornburgh, Jim Breyer's Breyer, Kinjo, Laura Malcolm, Kinjo's, Malcolm said, Krishna Srinivasan Organizations: Austin, LiveOak Venture Partners, Silverton Partners, Jim Breyer's Breyer Capital, Roble, Robux, Roblox Locations: Roblox, Silverton, Austin , Texas, Fortnite
He collapsed from heart failure while working at his restaurant, Andrew Bellucci’s Pizzeria, in Astoria, said Matthew Katakis, his business partner. He was pronounced dead at a hospital a short time later. Mr. Bellucci’s pizzas first won attention when he worked at Lombardi’s, a revival of a venerable coal-fired pizzeria on Spring Street in Little Italy. Nancy Silverton, Todd English and other chefs came to to taste his pizza, which was a far cry from the foldable, gold-and-orange and mostly interchangeable slices sold across the city. Ms. Silverton was especially impressed by a pie topped with fresh clams, garlic, oregano and olive oil.
Persons: Andrew Bellucci, Andrew Bellucci’s, Matthew Katakis, Nancy Silverton, Todd English, Silverton, Eric Asimov Organizations: New York Times Locations: New York City, Queens, Astoria, Lombardi’s, Little Italy
Yotam Ottolenghi Celebrates Spring With Asparagus
  + stars: | 2023-05-10 | by ( Yotam Ottolenghi | ) www.nytimes.com   time to read: +1 min
In her cookbook “Salt, Fat, Acid, Heat,” Samin Nosrat reduces two cups of heavy cream — add olive oil and Parmesan in very generous amounts — in an asparagus-and-mint pasta. Alice B. Toklas tossed her asparagus in melted butter and heavy cream. But as she served it, she whipped up some more heavy cream, seasoned with salt and pepper, to ward off any false sense of restraint. You can take a minimalist approach and roast your asparagus spears with some oil and salt. I also love Alice Waters’s classic salad of raw, thinly shaved asparagus with vinaigrette and Parmesan.
Instead of using kitchen vans, Wonder is preparing chef-driven meals from a storefront. Lore, who cofounded the e-commerce site Jet.com and sold it to Walmart, had plans to expand Wonder to a fleet of 1,000 kitchen vans. Storefronts can offer consumers up to 30 food brands for delivery from one location, while the van model was limited to two menus per van. ClusterTruck, a Midwest ghost kitchen that controls everything from the food recipes to delivery, is another model similar to Wonder. Still, Lore sees the value of marketing Wonder's food brands on delivery apps.
REUTERS/Siphiwe SibekoSILVERTON, South Africa, Jan 26 (Reuters) - U.S. Treasury Secretary Janet Yellen on Thursday lauded the Ford Motor Co's 100-year history of assembling vehicles in South Africa and underscored Washington's resolve to expand trade ties with countries that it "can count on," including South Africa. About 600 U.S. companies operate in South Africa, employing about 220,000 people and generating revenue equivalent to about 10% of South Africa's entire gross domestic product, U.S. Ambassador to South Africa Reuben Brigety said at the event. As in her comments to South Africa's finance minister earlier on Thursday, Yellen did not address South Africa's refusal to take sides over Russia's war in Ukraine or Washington's concern over military exercises it plans with China and Russia. That includes our many trusted trading partners on this continent — like South Africa."
Burger King's owner recently opened its first ghost kitchen, or digital food hall, in Miami. And recently, the parent of Burger King, Restaurant Brands International, opened its first ghost kitchen in Miami. Wonder is part ghost kitchen, part food delivery van, part meal-kit provider. These ghost kitchens on wheels, outfitted with cooking equipment and chefs, can be hailed through an app. The company, which ended its partnership with Miami-based Reef Technology this year, is not labeling the facility as a ghost kitchen.
Mortgage rates have risen rapidly over the past few months, though recently they've been more volatile. As the Federal Reserve gears up for another hike to the federal funds rate on Wednesday, mortgage rates remain elevated. See more mortgage rates on Zillow Real Estate on ZillowMortgage calculatorUse our free mortgage calculator to see how today's mortgage rates will affect your monthly and long-term payments. If the Fed acts too aggressively and engineers a recession, mortgage rates could fall further than what current forecasts expect. This means your entire monthly mortgage payment, including taxes and insurance, shouldn't exceed 28% of your pre-tax monthly income.
Thanks to high inflation and large rate hikes from the Federal Reserve, mortgage rates have increased dramatically this year. See more mortgage rates on Zillow Real Estate on ZillowMortgage refinance rates todayMortgage type Average rate today This information has been provided by Zillow. See more mortgage rates on Zillow Real Estate on ZillowMortgage calculatorUse our free mortgage calculator to see how today's mortgage rates will affect your monthly and long-term payments. Whether mortgage rates will drop in 2023 hinges on if the Federal Reserve can get inflation under control. If the Fed acts too aggressively and engineers a recession, mortgage rates could fall further than what current forecasts expect.
Average 30-year fixed mortgage rates are holding steady above 7%. And, in general, we see mortgage rates fall when there is a weak economy or a recession." Whether mortgage rates will drop in 2023 hinges on if the Federal Reserve can get inflation under control. If the Fed acts too aggressively and engineers a recession, mortgage rates could fall further than what current forecasts expect. This means your entire monthly mortgage payment, including taxes and insurance, shouldn't exceed 28% of your pre-tax monthly income.
Why you should reinstate the classic alarm clock
  + stars: | 2022-07-24 | by ( Jessica Bumpus | ) edition.cnn.com   time to read: +7 min
“You use an actual alarm clock?” they asked, as though it was a fax machine. It was years later, in 1874, when the French inventor Antoine Redier became the first person to patent an adjustable mechanical alarm clock. German clockmakers reportedly soon followed and by the end of the 1800s, the electric alarm clock had been invented. From riffs on the Panasonic RC-6025 radio alarm clock, immortalized in the 1993 film Groundhog Day, to more retro designs from classic brands like Roberts. All I was after, though, was a straightforward alarm clock, much like my original.
Persons: CNN —, I’d, you’re, , Lily Silverton, Levi Hutchins, ” Hutchins, Antoine Redier, Seth E, clockmakers, Roberts, Virgil Abloh’s, Braun, Dieter Rams, Dietrich Lubs, Paul Smith, “ It’s, , I’m Organizations: CNN, Deloitte, roosters, Panasonic, Dieter, “ Technology Locations: Britain, Concord , New Hampshire, French, Silverton
Burger King's owner recently opened its first ghost kitchen, or digital food hall, in Miami. Meet 7 nontraditional ghost kitchen startups. And, recently, the parent of Burger King, Restaurant Brands International, opened its first ghost kitchen in Miami. These ghost kitchens on wheels, outfitted with cooking equipment and chefs, can be hailed through an app. The company, which ended its partnership with Miami-based Reef Technology this year, is not labeling the facility as a ghost kitchen.
Zece californieni care se vaccinează înainte de această dată au ocazia să câştige premii în stil loterie în valoare de câte 1,5 milioane de dolari, în timp ce alte 30 de persoane vor câştiga fiecare 50.000 dolari. "Acest program este conceput pentru a-i încuraja pe cei care au nevoie de sprijin suplimentar pentru a se vaccina şi pentru a menţine California în siguranţă", a adăugat el. Stimulentele sunt oferite în timp ce Newsom luptă împotriva unei campanii de revocare care a devenit o cauză celebră printre republicani la nivel naţional. "Vaccinarea fiecărui californian eligibil este modul prin care putem face ca statul nostru să îşi revină după această pandemie", a precizat Newsom. Miercuri, Ohio a acordat 1 milion de dolari lui Abbigail Bugenske, o femeie din Silverton care a participat la tragerea "Vax-a-Million" organizată la nivelul acestui stat.
Persons: Gavin Newsom, doctorul Tomas Aragon, Miercuri, Abbigail, Joseph Costello Organizations: Reuters Locations: California, Statele Unite, siguranţă, SUA, Ohio, Inglewood
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